Dogs are an important model for understanding human cancer. One of the first steps in developing immunotherapies like checkpoint inhibitors and CAR T cells took place in dogs.
In recent weeks, a dog dewormer has come to the attention of the popular media because of claims that it cures cancer. The dewormer in question is fenbendazole, also known as Panacure or Safe-Guard.
Fenbendazole
Fenbendazole is a popular veterinary medication that’s effective against many helminth intestinal parasites. It’s also known as Panacur and Safe-Guard, and is sold in granule, chew, liquid, and capsule forms. It’s used to treat a variety of worms, including lungworms and flukes in cats. It can also be prescribed for dogs.
It works by inhibiting the polymerization of tubulin, which disrupts cytoskeletal structures and starves the parasite. It’s a popular option for treating parasites in pets because it is well-tolerated, doesn’t have serious side effects, and is relatively inexpensive.
It’s also being touted as a cancer treatment because it can suppress tumor growth and kill off parasites. However, this claim is unproven because no peer-reviewed studies have found that anthelmintics can cure cancer in humans. While preclinical research has been conducted, turning these results into an approved drug is a long journey.
Curcumin
NF-kB is activated by most inflammatory cytokines, gram-negative bacteria; various disease-causing viruses; high glucose; chemicals, physical, mechanical and psychological stress; environmental pollutants and cigarette smoke. Curcumin has been shown to inhibit NF-kB activation, and therefore reduce inflammation.
It has also been shown to reduce oxidative stress by inducing Nrf2 expression, which promotes antioxidant enzymes. Further, a recent animal study showed that curcumin enhanced the anticancer effects of 5-FU in gastric cancer xenografts by downregulating NF-kB activity.
When Joe Tippens first went public with his story of treating his cancer with a dewormer, many people were skeptical. But after two years, he still has no signs of cancer and says that his regimen—which includes fenbendazole, CBD oil, bioavailable curcumin and mega doses of Vitamin E—is working. In fact, he knows more than 50 other people using the same treatment plan and all are cancer free.
CBD Oil
CBD interacts with the dog’s endocannabinoid system and mimics the effects of cannabinoids that naturally occur in the body. It is also known to alleviate pain and anxiety caused by cancer and other conditions. It can help ease nausea, reduce the severity of seizures, and improve appetite. You can buy full-spectrum CBD oil for dogs that contains beneficial plant matter or isolates that are pure and have no flavor. To maximize absorption, it is best to administer the CBD oil by lifting your dog’s lip and allowing it to enter the mouth.
A Torquay man who was diagnosed with inoperable bowel cancer has been given a year or so to live thanks to a daily dose of CBD and a change in diet. His story has stunned doctors who were skeptical of the cure. The key is a process called apoptosis, which is when the body kills cells that are no longer healthy or needed.
Vitamin E
Vitamin E is an antioxidant that protects the cells from damage. It also has anti-inflammatory properties. It can be taken alongside chemotherapy to counteract the toxic effects of the treatment. It can also help prevent side effects from radiation. However, you should consult your vet before taking this supplement.
Fenbendazole is a popular broad-spectrum anthelmintic used to treat hookworms and other parasites. It was repurposed by Joe Tippens to cure cancer after he heard of a scientist who had cured her own cancer with this drug and other supplements. His protocol is now known as the Joe Tippens Protocol.
The drug works in a variety of ways, but the most significant is that it interferes with microtubules and starves malignant cells of their energy. It also impairs glucose uptake by blocking the cellular gateways that utilize sugar as energy. This effect is similar to that of taxanes and vinca alkaloids, but unlike these medications, fenbendazole does not affect p-glycoprotein expression.dog dewormer for cancer